ABSTRACT
Some of slimming drugs had been withdrawn from markets so, the present study was conducted to follow the effect of three different anorexic drugs; on the haematological and physical parameters of adults albino rats. The used drugs differ in their nature, where the first one i.e., apple-lite is a fully natural substance, the 2[nd] one i.e., mirapront-N. is a chemical substance and the 3[rd] one i.e., tenuate is a synthetic foamy filler substance. Fourty adult male albino rats [130 +/- 20g] were randomly divided into four groups, ten on each treated group and ten for the first group which conserved as control group. The 2[nd] group was treated daily with apple-lite [3.5 mg/ 100 g.b.wt], the 3[rd] group was treated daily with mirapro-N [0.14mg/100g.b.wt] and the 4[th] group was treated daily with tenuate [0.1 mg/100g.b.wt]. Haematological parameters [RBCs, WBCs count, haemoglobin content [Hb], hematocrit value [Hct%], mean cell volume [MCV], mean cell heamoglobin [MCH] and mean cell heamoglobin concentration [MCHC] were detected after 30 days of treatment and also after 15 days of the last treatment as a recovery period. Also, body weight, percent of organs weight/body weight, skin-fold thickness and some vital measurements i.e. heart beats, respiratory rate and rectal temperature were recorded after the same periods of treatment and recovery. Haematological studies revealed that RBCs count, total WBCs count, Hb and Hct values were significantly decreased in the three groups treated daily with anorexic drugs for 30 days. These changes aere also recorded after the recovery period except in apple-lite treated group which showed insignificant change in RBCs and Hb after the recovery period. The calculated mean cell haemoglobin concentration [MCHC] recorded significant increase in apple-lite after treated and recovery periods, while non significant changes in MCHC were observed after mirapront-N and tenuate groups after treatment 30 days for 30 days but significant increase of MCHC was recorded after the recovery period of tenuate treated group. Skin-fold thickness of the three regions tested [gluteal, back and belly] revealed significant decrease in all the treated groups except the belly region in apple-lite treated group which showed insignificant decrease after treatment for 30 days. Significant decrease of skin-fold thickness of different regions still present after the recovery period of 15 days in the three treated groups except the back region of mirapro-N and the belly region of apple-lite- treated rats which showed insignificant decrease. Percent of organs weight/body weight were affected according the type of tested drug, while apple-lite- caused non significant changes, mirapront-N caused significant increase in hepatosomatic ratio and cardiosomatic ratio, and significant decrease in gonadosomatic ratio. On the other hand, tenuate resulted in a significant increase in percentage weight of kidneys and hepatosomatic ratio and significant decrease of gonadosomatic ratio after treatment for 30 days. After the recovery period, apple-lite revealed significant decrease in brain/b.wt. ratio, while mirapront-N still affected kidneys, gonadosomatic ratio and brain and tenuate still affected gonadosomatic ratio and brain; they recorded significant decrease. The physical measurement of vital signs, i.e. heart rate, respiratory rate and rectal temperature recorded insignificant change after treatment with apple-lite, mirapro-N and tenuate for 30 days, but significant increase of rectal temperature was recorded in the tenuate group of the treated rats. After recovery period insignificant changes in heart rate, respiratory rate and rectal temperature of the treated rats were observed in the three treated groups